I finally found a solution given by Ronok in this post.
Following the full steps is not necessary, I had sane and most things associated with it already installed.
sudo gedit /etc/sane.d/dll.conf
Then find "epson" and "epson2"
Comment out "epson2" and uncomment "epson" so you are left with:
I rebooted but I'm unsure if that is required, afterwards XSane worked perfectly as it had for years.